Over the past 110 years, 37 244 girls have been named Serena. The name Serena ranks 629th in the United States among the most common names for girls. For the first time more than ten times newborns were named Serena in 1917. The peak of popularity of the name Serena came in the 1990s and 2000s. You can see absolute numbers and relative numbers on the chart. Indicators per 100K more accurately assess the popularity of the name.